Shank3 is a core excitatory postsynaptic protein expressed in multiple brain regions including the medial prefrontal cortex, striatum, and hippocampus. We have previously generated and characterized Shank3-overexpressing transgenic mice, and found that these mice exhibited manic-like behavioral phenotypes and increased food intake. To understand molecular mechanisms underlying the behavioral changes, we performed transcriptome (RNA-sequencing) analysis of the hypothalamic tissues from 10 to 12-week-old wild-type and Shank3 transgenic mice. SOURCE: Kihoon Han (neurohan@korea.ac.kr) -  Korea University College of Medicine

Pluto Bioinformatics

GSE120609: Hypothalamus transcriptome analysis of Shank3-overexpressing mice